Conbriza / Aprela

At a Glance
Therapeutic Area:
Women’s Health (osteoporosis)
Approved Applications:
NDA has been submitted, awaiting final FDA approval.
Applications In Development:
APRELA® (bazedoxifene in combination with PREMARIN®) is a progesterone-free treatment for menopausal symptoms. In July 2009 Phase III data showing that APRELATM significantly reduced the frequency and severity of hot flushes and improved measures of vaginal atrophy when compared to placebo was published in the journal Fertility and Sterility. An initial NDA is expected to be filed in the second half of 2010.
Acquisition Date:
March 2002
Royalty Seller:


"We are pleased to have successfully accelerated and increased the Royalty Pharma SERM option exercise based on the evolving product development timelines so that we have certainty of revenue and cash flow from the SERM royalty purchase, enabling us to complete the ONTAK royalty buydown/restructuring which is expected to be accretive in 2005 and beyond without significant reductions in our operating cash reserves," said Paul V. Maier, Ligand’s Senior Vice President and Chief Financial Officer. "Revenue and cash from the SERM royalty purchase in 2004 and recurring royalty income from our retained royalty interest which we expect in the 2005/2006 timeframe - following approval – represent the first royalty streams from our late-stage pipeline of corporate partner products. In addition to Pfizer’s recent NDA filing of lasofoxifene, we also believe Wyeth will proceed to NDA filing for bazedoxifene for prevention of osteoporosis in 2005, for treatment of osteoporosis in 2007, for combination bazedoxifene CE in 2007, and for Tanaproget in 2006. This progress underscores the maturation of our portfolio of eleven 'big drugs' in human development which resulted from our first decade of collaborative research programs and the diversity of potential future royalty income for our shareholders."
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